During the reign of Sree Moolam Thirunal, an Ayurvedic Patasala also known as Kashayappura was started (in 1889) at East Fort, Thiruvananthapuram. This later came became the Government Ayurveda College. Earlier only 15 students were given training yearly. In 1910 the college began to impart a five-year regular course and those who completed the first four years were awarded L.M.C (Lower Medical Certificate) certificate and those who completed all the five years were given Higher Medical Certificate. From 1917 onwards the degree course was titled "Vaidyakalanidhi". Later the college opened an outpatient counter and pharmacy both of which provided service to the public. The college in 1929 introduced a research degree named 'Ayurvedacharya'. The college has a library which has a fabulous collection of books and periodicals. The college celebrated its centenary in the 1989.