The College established in 1963 in the private sector was taken over by the government in 1972. It is the fourth Medical College in the state. The District Hospital Alappuzha is used as Medical College Hospital for the clinical training of students. The total bed strength in Medical College Hospital, Alappuzha is 844 and at Medical College Hospital, Vandanam 82. A new hospital complex was constructed at Neerkunnam at an estimate of Rs. 22.5 crores. Several equipment as Ultra Sound Scanner, Echo Cardiogram with colour dopler, Treadmill Exercise Machine, 1000 MA X-ray machine, Cobalt 60 machine, Electro encephalogram are available in the hospital. An institute of Virology and infectious diseases is coming up in the Medical College Campus. Under the scheme 24-hour lab service, Casualty Service upgradation, improvement of Central Library, upgradation of different specialities, Biomedical Engineering, Snakebite Treatment upgradations, Academic Development of P.G. Course, upgradation of Blood Bank and CME programme are provided.